Humanina vs MOTS-c
Humanina is mainly studied for cytoprotection, longevity, metabolism. while MOTS-c is studied for metabolic efficiency, energy, body composition. The difference is in the mechanism and the evidence, not in which is "better": it depends on the goal.
| Humanina | MOTS-c | |
|---|---|---|
| Category | Longevity/Cellular | Metabolic |
| Studied for | Cytoprotection, longevity, metabolism. | Metabolic efficiency, energy, body composition. |
| How it acts | A mitochondrial-derived peptide studied for its relationship with cytoprotection and signaling associated with longevity. | A mitochondrial-derived peptide studied for its relationship with metabolic efficiency, glucose homeostasis and cellular-energy signaling. |
| Evidence level | Preclinical evidence only | Limited human evidence |
How they differ
Although sometimes mentioned together, Humanina and MOTS-c do not target the same thing. Humanina: A mitochondrial-derived peptide studied for its relationship with cytoprotection and signaling associated with longevity. MOTS-c: A mitochondrial-derived peptide studied for its relationship with metabolic efficiency, glucose homeostasis and cellular-energy signaling.
See full entry: Humanina → · See full entry: MOTS-c →
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What is the main difference between Humanina and MOTS-c?
Humanina targets cytoprotection, longevity, metabolism. and MOTS-c targets metabolic efficiency, energy, body composition. They act through different pathways, so the choice depends on your goal, not on which is "stronger".
Can they be studied together?
Combinations are studied by goal in the literature, but combining is not just adding: it changes the safety profile. What to combine and how is decided with a professional; here we only explain what each is studied for.
Which has more human evidence?
Based on the references we verified, MOTS-c has more human studies of this pair. Each one's evidence level is in the table above, and the references with their PMID are at the end.
Other comparisons
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References
Every entry links to its record on PubMed, the US National Library of Medicine database. Open them and check. We would rather have a reader who verifies than one who takes our word for it.
- A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abetapreclinical Proc Natl Acad Sci U S A · 2001 · PMID 11371646 →
- Humanin: a novel central regulator of peripheral insulin actionpreclinical PLoS One · 2009 · PMID 19623253 →
- The mitochondrial derived peptide humanin is a regulator of lifespan and healthspanpreclinical Aging (Albany NY) · 2020 · PMID 32575074 →
- IGF-I regulates the age-dependent signaling peptide humaninpreclinical Aging Cell · 2014 · PMID 25040290 →
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistancepreclinical Cell Metab · 2015 · PMID 25738459 →
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stresspreclinical Cell Metab · 2018 · PMID 29983246 →
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humanshuman J Appl Physiol (1985) · 2021 · PMID 34351816 →
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationreview Front Endocrinol (Lausanne) · 2023 · PMID 36761202 →
Educational content. It does not include doses, protocols or preparation: that is defined by a professional.