AOD-9604 vs MOTS-c
AOD-9604 is mainly studied for body composition, lipid metabolism. while MOTS-c is studied for metabolic efficiency, energy, body composition. The difference is in the mechanism and the evidence, not in which is "better": it depends on the goal.
| AOD-9604 | MOTS-c | |
|---|---|---|
| Category | Metabolic | Metabolic |
| Studied for | Body composition, lipid metabolism. | Metabolic efficiency, energy, body composition. |
| How it acts | A fragment derived from a portion of growth hormone, studied for its relationship with lipid-metabolism pathways. | A mitochondrial-derived peptide studied for its relationship with metabolic efficiency, glucose homeostasis and cellular-energy signaling. |
| Evidence level | Preclinical evidence only | Limited human evidence |
How they differ
Although sometimes mentioned together, AOD-9604 and MOTS-c do not target the same thing. AOD-9604: A fragment derived from a portion of growth hormone, studied for its relationship with lipid-metabolism pathways. MOTS-c: A mitochondrial-derived peptide studied for its relationship with metabolic efficiency, glucose homeostasis and cellular-energy signaling.
See full entry: AOD-9604 → · See full entry: MOTS-c →
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What is the main difference between AOD-9604 and MOTS-c?
AOD-9604 targets body composition, lipid metabolism. and MOTS-c targets metabolic efficiency, energy, body composition. They act through different pathways, so the choice depends on your goal, not on which is "stronger".
Can they be studied together?
Combinations are studied by goal in the literature, but combining is not just adding: it changes the safety profile. What to combine and how is decided with a professional; here we only explain what each is studied for.
Which has more human evidence?
Based on the references we verified, MOTS-c has more human studies of this pair. Each one's evidence level is in the table above, and the references with their PMID are at the end.
Other comparisons
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References
Every entry links to its record on PubMed, the US National Library of Medicine database. Open them and check. We would rather have a reader who verifies than one who takes our word for it.
- Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormonepreclinical Horm Res · 2000 · PMID 11146367 →
- Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragmentpreclinical Int J Obes Relat Metab Disord · 2001 · PMID 11673763 →
- The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out micepreclinical Endocrinology · 2001 · PMID 11713213 →
- AOD-9604 Metabolicreview Curr Opin Investig Drugs · 2004 · PMID 15134286 →
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistancepreclinical Cell Metab · 2015 · PMID 25738459 →
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stresspreclinical Cell Metab · 2018 · PMID 29983246 →
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humanshuman J Appl Physiol (1985) · 2021 · PMID 34351816 →
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationreview Front Endocrinol (Lausanne) · 2023 · PMID 36761202 →
Educational content. It does not include doses, protocols or preparation: that is defined by a professional.