5-Amino-1MQ: what it is and what the evidence says
A small molecule, with no amino acids, that inhibits the NNMT enzyme in fat tissue and the liver and preserves the nicotinamide the cell needs to make NAD. It is studied for its relationship with energy metabolism and body composition.
Last reviewed: August 16, 2026 · How we verify this
The ground it plays on
Metabolism is not a single lever. Talk about metabolic compounds usually collapses three separate mechanisms into one word. Appetite regulation is one. How well cells respond to insulin is another, and largely independent of the first. Mobilizing stored fat is a third. A compound may act on one and leave the other two untouched, so knowing which one is the difference between understanding a molecule and reciting its name.
What it is studied for
Metabolism, body composition, energy.
There is a distinction that almost always gets lost. A compound being studied for something is not the same as achieving it. And even where it works in a dish or in a mouse, that says little about whether it works in a person or whether the benefit is worth the risk. The section below therefore carries more weight than everything above it.
What the human evidence says
There are no published clinical trials in people yet. The evidence on this inhibitor of the NNMT enzyme comes from cell cultures, from mice, and from one pharmacokinetic study in rats.
The limitation that matters most
Its pharmacokinetics, tolerability, and long-term safety in people remain to be studied. In mice, the most complete fat loss came when it was added to a change of diet, and the largest strength gain when it was added to exercise.
Regulatory status
Not approved by any regulatory agency. In the United States it is not on the lists of substances for pharmacy compounding, and the FDA restated this in a January 2026 letter to an outsourcing facility. WADA does not name it, but because it lacks approval it falls under section S0, prohibited at all times in sport.
Status can change and varies by country. Always verify the rules in force where you live before drawing conclusions.
Cautions and context
Early-stage research, with no trials in people yet. Because it changes how methyl groups are spent, homocysteine, vitamin B12, folate, and liver tests are monitored; the iodide salt supplies iodine.
With metabolic conditions, liver or thyroid disease, pregnancy, or ongoing medication, suitability is assessed with a professional before considering it.
What this page cannot give you
A reference page can take you this far. You know what 5-Amino-1MQ is and where its research stands, which already puts you ahead of most readers. Four questions remain that no encyclopedia can answer for you, because the answers depend on your own situation:
- What would you measure beforehand, so that later you could tell whether anything actually changed?
- What would you watch along the way, and how consistently?
- What would you ask a professional, and in how much detail, so you do not walk out with a textbook answer?
- What would make you stop?
That is what the course is for
PeptiXtreme is ${CIF.LECCIONES} lessons that hand out no numbers. Each one ends with your starting point, what to watch along the way, the specific questions you take to a professional and the signals that mean stop. It includes per-module exams, a Certificate of Completion with a verifiable certificate ID, a Progress Tracker to follow how you are doing, and a human advisor you can actually write to.
See the course → Or measure your judgment, freeReferences
Every entry links to its record on PubMed, the US National Library of Medicine database. Open them and check. We would rather have a reader who verifies than one who takes our word for it.
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in micepreclinical Biochem Pharmacol · 2018 · PMID 29155147 →
- Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal musclepreclinical Biochem Pharmacol · 2019 · PMID 30753815 →
- Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese micepreclinical Sci Rep · 2021 · PMID 33707534 →
- Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO micepreclinical Sci Rep · 2022 · PMID 35013352 →
- Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorderspreclinical Sci Rep · 2022 · PMID 36104373 →
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctionpreclinical Diabetes Obes Metab · 2024 · PMID 39161060 →
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Frequently asked questions
What is 5-Amino-1MQ?
A small molecule, with no amino acids, that inhibits the NNMT enzyme in fat tissue and the liver and preserves the nicotinamide the cell needs to make NAD. It is studied for its relationship with energy metabolism and body composition. It is studied within the area of metabolic.
Is there human evidence for 5-Amino-1MQ?
There are no published clinical trials in people yet. The evidence on this inhibitor of the NNMT enzyme comes from cell cultures, from mice, and from one pharmacokinetic study in rats.
Is it approved by any health agency?
Not approved by any regulatory agency. In the United States it is not on the lists of substances for pharmacy compounding, and the FDA restated this in a January 2026 letter to an outsourcing facility. WADA does not name it, but because it lacks approval it falls under section S0, prohibited at all times in sport.
What is the dose of 5-Amino-1MQ?
We do not publish dosages. This is not an oversight. No single figure works for everyone: the regimen depends on a person's medical history, on whatever medication they already take, and on the goal they are chasing, which is something a professional weighs with the case in front of them. What you can build is the ability to walk into that appointment knowing what to ask.
Where can I learn to evaluate this properly?
This page tells you what 5-Amino-1MQ is and what the evidence says. The PeptiXtreme course teaches the other half: what you would measure before considering anything, what you would watch, the specific questions you would take to a professional and when you would stop.