Folistatina (FST) vs IGF-1 LR3
Folistatina (FST) is mainly studied for muscle development, composition. while IGF-1 LR3 is studied for muscle growth, recovery. The difference is in the mechanism and the evidence, not in which is "better": it depends on the goal.
| Folistatina (FST) | IGF-1 LR3 | |
|---|---|---|
| Category | Regenerative | Hormonal/Sexual |
| Studied for | Muscle development, composition. | Muscle growth, recovery. |
| How it acts | A protein studied for its relationship with myostatin regulation and signals associated with muscle development. | An analog of insulin-like growth factor, studied for its relationship with growth and muscle-repair signaling. |
| Evidence level | Limited human evidence | Limited human evidence |
How they differ
Although sometimes mentioned together, Folistatina (FST) and IGF-1 LR3 do not target the same thing. Folistatina (FST): A protein studied for its relationship with myostatin regulation and signals associated with muscle development. IGF-1 LR3: An analog of insulin-like growth factor, studied for its relationship with growth and muscle-repair signaling.
See full entry: Folistatina (FST) → · See full entry: IGF-1 LR3 →
Want to truly understand it, not memorize it?
The course explains each peptide at a university level: how it acts, what outcomes are studied, what it combines with and when to pause. No doses: the protocol is defined by a professional.
See the course → Start with the free test →Frequently asked questions
What is the main difference between Folistatina (FST) and IGF-1 LR3?
Folistatina (FST) targets muscle development, composition. and IGF-1 LR3 targets muscle growth, recovery. They act through different pathways, so the choice depends on your goal, not on which is "stronger".
Can they be studied together?
Combinations are studied by goal in the literature, but combining is not just adding: it changes the safety profile. What to combine and how is decided with a professional; here we only explain what each is studied for.
Which has more human evidence?
Based on the references we verified, Folistatina (FST) has more human studies of this pair. Each one's evidence level is in the table above, and the references with their PMID are at the end.
Other comparisons
Was this page useful?
Research moves, and when something relevant changes we update the page. If you want to hear about it for Folistatina (FST) vs IGF-1 LR3 or any other compound, leave your email. The introductory guide comes with it. No spam, no list-selling; one click to unsubscribe.
References
Every entry links to its record on PubMed, the US National Library of Medicine database. Open them and check. We would rather have a reader who verifies than one who takes our word for it.
- Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomeshuman Mol Ther · 2017 · PMID 28279643 →
- A phase 1/2a follistatin gene therapy trial for becker muscular dystrophyhuman Mol Ther · 2015 · PMID 25322757 →
- The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis Physiol Behav · 2023 · PMID 37328021 →
- Regulation of myostatin activity and muscle growthpreclinical Proc Natl Acad Sci U S A · 2001 · PMID 11459935 →
- Detection of His-tagged Long-R3-IGF-I in a black market productpreclinical Growth Horm IGF Res · 2010 · PMID 20675162 →
- Biochemical markers of insulin-like growth factor-I misuse in athletes: the response of serum IGF-I, procollagen type III amino-terminal propeptide, and the GH-2000 score to the administration of rhIGF-I/rhIGF binding protein-3 complexhuman J Clin Endocrinol Metab · 2014 · PMID 24606087 →
- Frequency and Predictive Factors of Hypoglycemia in Patients Treated With rhIGF-1: Data From the Eu-IGFD Registryhuman J Clin Endocrinol Metab · 2023 · PMID 37579214 →
- Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effectsreview Mol Cell Endocrinol · 2018 · PMID 28606865 →
Educational content. It does not include doses, protocols or preparation: that is defined by a professional.